Interleukin 4 inhibits the production of some acute‐phase proteins by human hepatocytes in primary culture

FEBS Letters

Loyer, Pascal²  Razzak, Ziad Abdel²  Dezier, Jean-François²  Guillouzo, André²  Banchereau, Jacques¹  Guguen-Guillouzo, Christiane²  Campion, Jean-Pierre²  Ilyin, Gennady² 

[1] Schering-Plough, Laboratoire de Recherches Immunologiques, 27 Chemin des Peupliers, 69571 Dardilly Cedex, France;Institut National de la Santé et de la Recherche Médicale', Unité de Recherches Hépatologiques U-49, Hôpital Pontchaillou, 35033 Rennes Cedex, France

关键词: Interleukin 4;    Interieukin 6;    Acute phase protein;    Human hepatocytes;    Primary culture;   

DOI  :  10.1016/0014-5793(93)80806-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Interleukin 4 (IL4) has been shown to exhibit anti-inflammatory effects by inhibiting the secretion by monocytes of proinflammatory cytokines such as interieukin 1 (IL1), interleukin 6 (IL6), and tumor necrosis factor (TNF) and by inducing the secretion of the IL1 receptor antagonist. We investigated the role of this cytokine on the production of acute-phase proteins in primary human hepatocyte cultures. Cells were exposed to either IL4 and/or IL6, the most potent mediator of hepatic acute phase proteins. IL4 led to decreased production of haptoglobin, C-reactive protein and albumin while α1-antitrypsin and fibrinogen remained unaffected. These inhibitory effects of IL4 were also observed at the mRNA level. In addition, IL4 inhibited the IL6-induced production of haptoglobin although it had no effect on the induced C-reactive protein and fibrinogen. Our results demonstrate that IL4 can affect the production of a subset of acute-phase proteins by human hepatocytes and can antagonize some of the effects of IL6. These observations reinforce the notion that IL4 can be considered as an anti-inflammatory cytokine.

【 授权许可】

Unknown