Na+,K+‐ATPase of gastric cells A target of Helicobacter pylori cytotoxic activity

FEBS Letters

Romano, M.²  Solcia, E.³  Ricci, V.¹  Ventura, U.¹  Fiocca, R.³  Sommi, P.¹  Ivey, K.J.⁴  Cova, E.¹ 

[1] Institute of Human Physiology, University of Pavia, I-27100 Pavia, Italy;Department of Medicine, University of Naples, I-80131 Naples, Italy;Department of Human Pathology, University of Pavia, I-27100 Pavia, Italy;Department of Medicine, VAMC, Long Beach, CA 90822, USA

关键词: Na+;    K+-ATPase;    Helicobacter pylori;    Cytotoxicity;    Cell vacuolation;    K+-dependent phosphatase activity;    Cultured gastric cells;   

DOI  :  10.1016/0014-5793(93)81703-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The present study shows a direct impairing action of a cytotoxin-producing Helicobacter pylori strain on the Na⁺,K⁻-ATPase (evaluated as K⁺-dependent phosphatase activity) of human gastric epithelial cells in culture. The toxin itself is likely involved in this action which may also account for the cell edema found in vivo in Helicobacter pylori-colonized stomach.

【 授权许可】

Unknown