Negative correlation with liver cell division of a 38 kilodalton protein whose phosphorylation is enhanced by ras and G‐proteins

FEBS Letters

Das, M.R.¹  Hegde, Ashok N.¹  Swamy, Ch.V.B.¹  Murali Krishna, Bh.¹ 

[1] Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad 500 007, India

关键词: Cell division;    ras Protein;    Protein phosphorylation;    Level of p38;   

DOI  :  10.1016/0014-5793(93)80383-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We showed earlier that the phosphorylation of a 38 kDa protein (p38) from rat liver plasma membrane is stimulated by ras or endogenous G-proteins. We have now estimated the level of expression of p38 in liver tissues from embryos at different stages of development, regenerating liver and also in tumor cell lines of hepatic origin. Our results indicate that the expression of p38 is negatively correlated with cell division. It is suggested that the phosphorylation of p38, an event which is regulated by ras proteins and G-proteins, could be involved in signal transduction processes associated with the inhibitory regulation of cell division.

【 授权许可】

Unknown