Induction of phosphatidic acid by fibroblast growth factor in cultured baby hamster kidney fibroblasts

FEBS Letters

Motoike, Toshiyuki¹  Bieger, Sophie¹  Unsicker, Klaus¹  Wiegandt, Herbert² 

[1] Department of Anatomy and Cell Biology, University of Heidelberg, Im Neuenheimer Feld 307, D-69120 Heidelberg, Germany;Department of Physiological Chemistry, University of Marburg, Karl-von-Frisch Straße, D-35043 Marburg, Germany

关键词: Fibroblast growth factor;    Phosphatidic acid;    Phospholipase D;    BHK cell;    BHK cells;    baby hamster kidney cells;    DG;    diacylglycerol;    EGF;    epidermal growth factor;    FGF-2;    β-fibroblast growth factor;    IPS;    inositol 1;    4;    5-trisphosphate;    PA;    phosphatidic acid;    PC;    phosphatidylcholine;    PC-PLC;    phosphatidylcholine-specifie phospholipase C;    PDGF;    platelet-derived growth factor;    PI;    phosphatidylinositol;    PIP;    phosphatidylinositol 4-phosphate;    PIP2;    phosphatidylinositol 4;    5-bisphosphate;    PIPK;    phosphatidylinositol-4-phosphate kinase;    PI-PLC;    phosphatidylinositol-specific phospholipase C;    PI3K;    phosphatidylinositol 3-kinase;    PKC;    protein kinase C;    PLC-γ;    phospholipase C-γl;    PLD;    phospholipase D;    RasGAP;    Ras GTPase activating protein;   

DOI  :  10.1016/0014-5793(93)80505-O

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Basic fibroblast growth factor (bFGF/FGF-2) is a strong mitogenic inducer of cultured baby hamster kidney (BHK) cells. When cultured BHK cells were stimulated with FGF-2, phosphatidic acid (PA) was induced within 2 min, peaked at 5 min and gradually decreased. Phospholipase D (PLD) was also mitogenic for cultured BHK cells and this effect was mediated via PA. The possibility that PA induction by FGF-2 is an essential signaling step for BHK cell proliferation is discussed.

【 授权许可】

Unknown