Differential expression of AMPA glutamate receptor mRNAs in the rat adrenal gland

FEBS Letters

Kristensen, Peter¹ 

[1] Department of Pathology and Histochemistry, Pharmaceutical Division, Novo Nordisk AIS, Novo Nordisk Park G9 2.12, DK-2760 Måløv, Denmark

关键词: Glutamate receptor;    AMPA;    mRNA expression;    Hybridisation;    in situ;    Adrenal gland;    Rat;    AMPA;    α-amino-3-hydroxy-5-methyl-isoxazole-4-propionate;    GluR;    glutamate receptor;    NMDA;    N-methyl-d-aspartate;    PCR;    polymerase chain reaction;   

DOI  :  10.1016/0014-5793(93)80472-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Localisation of mRNA encoding the four AMPA glutamate receptor subunits in the rat adrenal gland was investigated using in situ hybridisation. GluR1 is found in the zona glomerulosa of the cortex, GluR3 in the remaining parts of the cortex, GluR2 in adrenal medullary cells and GluR4 at a very low level in the zona glomerulosa. All four receptor mRNAs are found in medullary ganglion cells. The flip form of GluR2 and GluR3 dominate and the GluR2 mRNA is present in the arginine encoding form. Different cell populations of the adrenal gland may express homomeric forms of different receptor subtypes.

【 授权许可】

Unknown