Repression of histone H5 gene expression in chicken mature erythrocytes is correlated with reduced DNA‐binding activities of transcription factors SP1 and GATA‐1

FEBS Letters

Davie, James R.¹  Penner, C.Gail¹  Sun, Jian-Min¹ 

[1] Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Manitoba, 770 Bannatyne Avenue, Winnipeg, Man., R3E 0W3, Canada

关键词: Transcription;    Transcription factor;    Gene expression;    Histone H5 gene;   

DOI  :  10.1016/0014-5793(93)80313-J

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

During the final stages of erythroid maturation, the expression of the chicken histone H5 gene ceases. The histone H5 promoter has binding sites for Sp1 and UPE-binding protein. The 3' histone H5 enhancer has binding sites for Sp1, GATA-1 and NF1. Here, we show that the DNA-binding activities of transcription factors Sp1 and GATA-1 is reduced 5- to 10-fold in mature cells, while the activities of UPE-binding protein and NF1 remain the same in mature and immature erythrocytes. The reduced activities of Sp1 and GATA-1 may contribute to the inactivation of the histone H5 gene in mature erythrocytes.

【 授权许可】

Unknown