FEBS Letters | |
Repression of histone H5 gene expression in chicken mature erythrocytes is correlated with reduced DNA‐binding activities of transcription factors SP1 and GATA‐1 | |
Davie, James R.1  Penner, C.Gail1  Sun, Jian-Min1  | |
[1] Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Manitoba, 770 Bannatyne Avenue, Winnipeg, Man., R3E 0W3, Canada | |
关键词: Transcription; Transcription factor; Gene expression; Histone H5 gene; | |
DOI : 10.1016/0014-5793(93)80313-J | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
During the final stages of erythroid maturation, the expression of the chicken histone H5 gene ceases. The histone H5 promoter has binding sites for Sp1 and UPE-binding protein. The 3' histone H5 enhancer has binding sites for Sp1, GATA-1 and NF1. Here, we show that the DNA-binding activities of transcription factors Sp1 and GATA-1 is reduced 5- to 10-fold in mature cells, while the activities of UPE-binding protein and NF1 remain the same in mature and immature erythrocytes. The reduced activities of Sp1 and GATA-1 may contribute to the inactivation of the histone H5 gene in mature erythrocytes.
【 授权许可】
Unknown
【 预 览 】
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RO201912020298480ZK.pdf | 437KB | download |