Caffeic acid phenethyl ester as a lipoxygenase inhibitor with antioxidant properties

FEBS Letters

Sud'ina, G.F.¹  Sumbatyan, N.V.¹  Pushkareva, M.A.¹  Varfolomeev, S.D.¹  Korshunova, G.A.¹  Mirzoeva, O.K.¹ 

[1] A.N. Belozersky Institute of Physico-Chemical Biology, Moscow State University, Moscow 119899, Russian Federation

关键词: Caffeic acid phenethyl ester;    5-Lipoxygenase;    Enzyme inhibition;    Respiratory burst;    Xanthine oxidase;    CAPE;    caffeic acid phenethyl ester;    NDGA;    nordihydroguaiaretic acid;    PMA;    phorbol 12-myristate 13-acetate;   

DOI  :  10.1016/0014-5793(93)80184-V

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Caffeic acid phenethyl ester, an active component of propolis extract, inhibits 5-lipoxygenase in the micromolar concentration range. The inhibition is of an uncompetitive type, i.e. the inhibitor binds to the enzyme-substrate complex but not to the free enzyme. Caffeic acid phenethyl ester also exhibits antioxidant properties. At a concentration of 10 μM, it completely blocks production of reactive oxygen species in human neutrophils and the xanthine/xanthine oxidase system.

【 授权许可】

Unknown