Determination of renal clearance of neopterin by a pharmacokinetic approach

FEBS Letters

Weiss, Günter³  Estelberge, Willibald²  Wächter, Helmut³  Reibnegger, Gilbert³  Paletta, Benno²  Petek, Walter¹ 

[1] Institut für Medizinische Biochemie, Universität Graz, Austria;Institut für Medizinische Chemie, Universität Graz, Austria;Institut für Medizinische Chemie, Universität Innsbruck, Austria

关键词: Neopterin;    Renal clearance;    Glomerular filtration;    Tubular secretion;    Pharmacokinetics;    Mathematical modelling;   

DOI  :  10.1016/0014-5793(93)80182-T

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Pharmacokinetic modelling was used to determine the glomerular filtration rate and tubular secretion of neopterin, a marker for cellular immune activation. The method involves parameter identification employing the transient venous plasma concentration profiles of marker substances. By combined i.v. injection of neopterin and inulin which is excreted exclusively via glomerular filtration, neopterin was shown to be excreted in addition to glomerular filtration, by tubular secretion: clearance of inulin, 112 (S.D. 2.2) ml/liter; clearance of neopterin, 499 (S.D. 79.7) ml/min. A pilot experiment using in addition p-amino hippuric acid suggests that neopterin and p-amino hippuric acid may employ the same carrier system for tubular secretion.

【 授权许可】

Unknown