Do cytosolic factors prevent promiscuity at the membrane surface?

FEBS Letters

Lithgow, Trevor¹  Høj, Peter B.¹  Hoogenraad, Nicholas J.¹ 

[1] Department of Biochemistry, La Trobe University, Bundoora 3083, Australia

关键词: Cytosolic factor;    Molecular chaperone;    Protein import;    Organelle biogenesis;    Protein sorting;    Heat-shock protein;   

DOI  :  10.1016/0014-5793(93)80179-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

From the point of view of a preprotein, escaping from the cytosol into a specific organelle must seem an arduous, almost impossible task. How is it that preproteins resist the temptation to fold prematurely, to avoid the multiple membrane surfaces in the cell, and manage instead to enter only the translocation apparatus of a single organelle?

【 授权许可】

Unknown