Growth hormone mediates zone‐specific gene expression in liver

FEBS Letters

Lindros, K.O.¹  Nikkola, E.¹  Oinonen, T.¹ 

[1] Biomedical Research Center, Alko Ltd, 00101 Helsinki, Finland

关键词: Hypophysectomy;    Rat;    Growth hormone;    Cytochrome P450 expression;    Liver zonation;    Perivenous;    EGF;    epidermal growth factor;    GH;    growth hormone;    hGH;    human recombinant growth hormone;   

DOI  :  10.1016/0014-5793(93)80176-U

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The CYP2B1/2 gene pair is an example of many liver genes that exhibit a characteristic zonated expression pattern in the liver. The factors governing this zonation are poorly understood. We observed that after hypophysectomy the expression of CYP2B1/2 protein and mRNA in the normally silent periportal (upstream) region was high, in both male and female rats. Treatment with growth hormone counteracted the effect of hypophysectomy, limiting expression to the perivenous (downstream) region, completely in females and partially in males. This shows that a hormone zone-specifically regulates gene expression in the liver.

【 授权许可】

Unknown