Protegrins: leukocyte antimicrobial peptides that combine features of corticostatic defensins and tachyplesins

FEBS Letters

Aleshina, Galina M.¹  Kokryakov, Vladimir N.³  Harwig, Sylvia S.L.³  Shamova, Olga V.¹  Panyutich, Elena A.³  Korneva, Helen A.¹  Lehrer, Robert I.³  Shevchenko, Andrei A.² 

[1] Department of General Pathology and Pathophysiology, Institute for Experimental Medicine, 197376 St. Petersburg, Russian Federation;Laboratory of Biochemical Researches, Institute for Analytical Instrumentation of the Academy of Sciences of the Russian Academy of Science, 198103 St. Petersburg, Russian Federation;Department of Medicine, UCLA, Los Angeles, CA 90024, USA

关键词: Leukocyte;    Phagocyte;    Antibiotic peptide;    Host-parasite relationship;   

DOI  :  10.1016/0014-5793(93)80175-T

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Porcine leukocytes contained three homologous peptides, PG-1, 2 and 3, that manifested potent microbicidal activity against Escherichia coli, Listeria monocytogenes and Candida albicans in vitro. The peptides (‘protegrins’) were composed of 16 (PG-2) or 18 amino acid residues, and, like tachyplesins (broad-spectrum antibiotic peptides of horseshoe crab hemocytes), they contained two intramolecular cystine disulfide bonds. Considerably smaller than defensins, protegrins nevertheless showed substantial homology to them, especially to the ‘corticostatic’ rabbit defensin, NP-3a. The relatively simple structure of protegrins should provide useful prototypes for constructing congeners with selectively enhanced host defense activities.

【 授权许可】

Unknown