Glutamate receptors of Drosophila melanogaster

FEBS Letters

Betz, Heinrich¹  Schmitt, Bertram¹  Ultsch, Andreas¹  Schuster, Christoph M.¹  Laube, Bodo¹ 

[1] Abteilung Neurochemie, Max-Planck-Institut für Hirnforschung, Deutschordenstrasse 46, D-6000 Frankfurt 71, Germany

关键词: Glutamate receptor;    NMDA receptor homologue;    Drosophila melanogaster;    AMPA;    α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid;    GluR;    glutamate receptor;    NMDA;    N-methyl-d-aspartate;    PCR;    polymerase chain reaction;   

DOI  :  10.1016/0014-5793(93)81387-F

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The NMDA subtype of ionotropic glutamate receptors has been implicated in the activity-dependent modification of synaptic efficacy in the mammalian brain. Here we describe a cDNA isolated from Drosophila melanogaster which encodes a putative invertebrate NMDA receptor protein (DNMDAR-I). The deduced amino acid sequence of DNMDAR-I displays 46% amino acid identity to the rat NMDAR1 polypeptide and shows significant homology (16–23%) to other vertebrate and invertebrate glutamate receptor proteins. The DNMDAR-I gene maps to position 83AB of chromosome 3R and is highly expressed in the head of adult flies. Our data indicate that the NMDA subtype of glutamate receptors evolved early during phylogeny and suggest the existence of activity-dependent synaptic plasticity in the insect brain.

【 授权许可】

Unknown