A distal region of the CALC‐1 gene is necessary for regulated alternative splicing

FEBS Letters

Horn, D.A.¹  Latchman, D.S.¹ 

[1]Division of Molecular Pathology, University College London Medical School, The Windeyer Building, Cleveland Street, London, W1P 6DB, UK

关键词: Alternative splicing;    Calcitonin;    Calcitonin gene related peptide;    Gene regulation;   

DOI  :  10.1016/0014-5793(93)81376-B

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The CALC-1 gene exhibits tissue specific alternative splicing with exons 1–4 being spliced to produce the calcitonin mRNA in thyroid C cells and exons 1–3 and 5–6 being joined to produce the CGRP mRNA in neuronal cells. Previous studies have identified an element in intron 3 within the alternatively spliced region which is critical for this effect to occur. We show here that deletion of sequences downstream of the alternatively spliced region also disrupts the tissue specific pattern of alternative splicing. The manner in which these sequences act is discussed.

【 授权许可】

Unknown