Prediction of a novel topology in the N‐terminal, 14 kDa fragment of ada protein

FEBS Letters

Swindells, Mark B.¹ 

[1] Protein Engineering Research Institute, 6-2-3 Furuedai, Suita, Osaka 565, Japan

关键词: Ada protein;    Topology;    Analysis;    Prediction;   

DOI  :  10.1016/0014-5793(93)81352-Z

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Previously determined protein structures have been analysed, in order to find folding motifs similar to that proposed by NMR spectroscopy, for the N-terminal, 14 kDa fragment of the Ada protein. The analyses reveal only limited similarities with the NMR-derived structural data and strongly suggest that this region of the Ada protein adopts a previously unobserved topology. Characteristic structural features, which arise from the inferred chain connectivity, are examined through comparisons with other structures. Using this information, the topology of the Ada protein 14 kDa fragment has been predicted in order to provide structural data not yet attainable from NMR experiments.

【 授权许可】

Unknown