Direct influence of morphine on the release of arachidonic acid and its metabolites

FEBS Letters

Terentjeva, I.V.¹  Varfolomeev, S.D.¹  Sergeeva, M.G.¹  Mevkh, A.T.¹ 

[1] A.N. Belozersky Institute of Physico-Chetnical Biology, Moscow State University, Moscow 119899, Russian Federation

关键词: Morphine;    Opioid;    Arachidonic acid metabolism;    Macrophage;   

DOI  :  10.1016/0014-5793(93)81471-B

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The influence of 10⁻¹⁰–10⁻⁶ M morphine on the release of [³H]arachidonic acid and its metabolites ([³H]AAM) from prelabeled resident peritoneal murine macrophages was investigated. Morphine enhanced [³H]AAM release from A23187- and LPS-stimulated macrophages, as well as the basal release of [³H]AAM. Dose-response curves showed a maximum at 10⁻⁸ M morphine. Naloxone had no effect on morphine enhancement of [³H]AAM release. These results are in agreement with the hypothesis that [³H]AAM may be involved in the effects of morphine.

【 授权许可】

Unknown