Human islet amyloid polypeptide transgenic mice as a model of non‐insulin‐dependent diabetes mellitus (NIDDM)

FEBS Letters

Heisserman, Judith A³  Nishi, Masahiro²  Steiner, Donald F.²  Ohagi, Shinyo²  Westermark, Gunilla T.¹  Leckström, Arnold¹  Westermark, Per¹  Chan, Shu Jin²  Fox, Niles³  Schrementi, James³ 

[1] Department of Pathology, Linkoping University, Linkoping, Sweden;Department of Biochemistry and Molecular Biology and Howard Hughes Medical Institute, University of Chicago, Chicago, IL 60637, USA;Department of Chemistry and Biotechnology Research, Lilly Research Labs, Lilly Corporate Center, Indianapolis, IN 46285, USA

关键词: Transgenic mouse;    Islet amyloid polypeptide;    Amylin;    Non-insulin-dependent diabetes mellitus;    Islet amyloid;    Islet of Langerhans;   

DOI  :  10.1016/0014-5793(93)81444-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

To model islet amyloidogenesis in NIDDM and explore the glucoregulatory role of islet amyloid polypeptide (IAPP), we have created transgenic micye containing a rat insulin-I promoter-human IAPP fusion gene. Expression of human IAPP was localized to the islets of Langerhans, anterior pituitary and brain in transgenic animals; blood IAPP levels were elevated 5-fold while fasting glucose levels remained normal. Amyloid deposits have not been detected in transgenic islets suggesting that other co-existing abnormalitites in NIDDM may be required for the formation of islet amyloid. These animals provide a unique model for exploring this hypothesis and other proposed functions of IAPP.

【 授权许可】

Unknown