Differanisole A, an inducer of the differentiation of Friend leukemic cells, induces stalk cell differentiation in Dictyostelium discoideum

FEBS Letters

Takahashi, Nobutaka²  Asahi, Ken-ichi²  Kubohara, Yuzuru³  Okamoto, Koji³  Tanaka, Yoshimasa¹  Sakurai, Akira² 

[1] Institute of Biological Sciences, University of Tsukuba, Ibaraki 305, Japan;The Institute of Physical and Chemical Research (RIKEN), Wako-shi, Saitama 351-01, Japan;Department of Botany, Faculty of Science, Kyoto University, Kyoto 606, Japan

关键词: Cellular slime mould;    Dictyostelium discoideum;    Differentiation inducing factor;    Differanisole A;    Chaetomium;    Leukemia cell;   

DOI  :  10.1016/0014-5793(93)81114-F

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Differanisole A isolated from the conditioned medium of a soil microorganism, Chaetomium strain RB-001, is an inducer of the differentiation of the Friend leukemic cells (mouse leukemia cells). The chemical structure of this substance is very similar to that of stalk cell differentiation-inducing factor (DIF) isolated from the cellular slime mould, Dictyostelium discoideum. We examined the effects of differanisole A on Dictyostelium HM44 cells, a mutant strain which is defective in DIF production, and found this substance to be an inducer of stalk cell differentiation in D. discoideum.

【 授权许可】

Unknown