OSBPa, a predicted oxysterol binding protein of Dictyostelium, is required for regulated entry into culmination

FEBS Letters

Fukuzawa, Masashi¹  Williams, Jeffrey G.¹ 

[1] School of Life Sciences, University of Dundee, Wellcome Trust Biocentre, Dow Street, Dundee DD1 5EH, UK

关键词: Oxysterol binding protein;    ‘Slugger’ mutant;    Culmination;    Dictyostelium discoideum;    OSBP;    oxysterol binding protein;    pstO;    prestalk O;   

DOI  :  10.1016/S0014-5793(02)03150-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The oxysterol binding proteins (OSBPs) are believed to control cholesterol homeostasis but their precise mechanism of action is not well understood. The Dictyostelium osbA gene encodes a predicted OSBP, OSBPa, which lacks the PH domain that in most other OSBPs directs targetting to the Golgi. OSBPa instead localises selectively to the cell periphery and also, in some cells, to the perinuclear region. OSBPa null strains form normal fruiting bodies but are defective in the regulation of the transition from slug migration to culmination. Thus a plasma membrane-enriched OSBP family member is essential for correct regulation of the slug–fruiting body switch.

【 授权许可】

Unknown