Metabolic channelling and control of the flux

FEBS Letters

Westerhoff, Hans V.¹  Kholodenko, Boris N.¹ 

[1] E.C. Slater Institute, University of Amsterdam, Plantage Muidergracht 12, Amsterdam, The Netherlands

关键词: Metabolic control theory;    Control coefficient;    Direct transfer;    Enzyme-enzyme interaction and kinetics;   

DOI  :  10.1016/0014-5793(93)81660-R

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Metabolic control theory is extended to include channelled metabolism in general. A simple relationship between the flux control by the enzymes and the degree of metabolite channelling is derived. This relationship suggests experiments in which modulation of gene expression allows one to quantify channelling.

【 授权许可】

Unknown