期刊论文详细信息
FEBS Letters
SC‐0051, a 2‐benzoyl‐cyclohexane‐1,3‐dione bleaching herbicide, is a potent inhibitor of the enzyme p‐hydroxyphenylpyruvate dioxygenase
Beyer, Peter1  Kleinig, Hans1  Ort, Oswald2  Schulz, Arno2 
[1] Institut für Biologie II, Universität Freiburg, D-7800 Freiburg i.Br., Germany;Hoechst AG, 6230 Frankfurt/Main 80, Germany
关键词: p-Hydroxyphenylpyruvate dioxygenase;    Phytoene desaturase;    Enzyme inhibition;    Herbicide;    SC-0051;   
DOI  :  10.1016/0014-5793(93)80013-K
学科分类:生物化学/生物物理
来源: John Wiley & Sons Ltd.
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【 摘 要 】

Growth inhibition of Lemna gibba plantlets by the bleaching herbicide, SC-0051 (2-(2-chloro-4-methanesulfonylbenzoyl)-1,3-cyclohexanedione)) was alleviated by the addition of homogentisic acid to the growth medium. Homogentisic acid is a key intermediate in the biosynthesis of tyrosine-derived plant quinones as well as in tyrosine metabolism. The herbicide prevented the incorporation of radioactivity from [14C]tyrosine into lipophilic plant metabolites and, in rat liver extracts, the herbicide inhibited the conversion of tyrosine to homogentisic acid. The enzyme p-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27) from both Zea mays seedlings and liver tissues, was found to be subject to strong inhibition by SC-0051. Inhibition of plant quinone biosynthesis is a new mode of herbicidal action. One of the consequences of quinone depletion in plants in vivo is apparently an indirect inhibition of phytoene desaturation. The enzyme phytoene desaturase itself, however, is not afflicted by the herbicide.

【 授权许可】

Unknown   

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