Growth response to 4‐hydroxy‐l‐threonine of Escherichia coli mutants blocked in vitamin B6 biosynthesis

FEBS Letters

Leistner, Eckhard²  Drewke, Christel²  Hansen, Ursula²  Spenser, Ian D.¹  Hemscheidt, Thomas¹  Hill, Robert E.³  Notheis, Caroline² 

[1] Department of Chemistry, McMaster University, Hamilton, Ont., L8S 4M1, Canada;Institut für Pharmazeutische Biologie, Universität Bonn, D-5300 Bonn 1, Germany;Department of Pathology, McMaster University, Hamilton, Ont., L8S 4M1, Canada

关键词: Biosynthesis;    Escherichia coli;    Vitamin B6;    Pyridoxol;    4-Hydroxy-l-threonine;    1-Aminopropan-2;    3-diol;   

DOI  :  10.1016/0014-5793(93)80005-F

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Mutants of Escherichia coli (pdx B and pdx C) which are blocked in the biosynthesis of pyridoxol (vitamin B₆) showed a growth response to 4-hydroxy-l-threonine. This observation constitutes the first direct evidence in support of the view that 4-hydroxy-l-threonine is implicated in the biosynthesis of vitamin B₆. 1-Aminopropan-2,3-diol, the decarboxylation product of 4-hydroxy-l-threonine, does not support the growth of these mutants. Deuterium from deuterium-labelled 1-aminopropan-2,3-diol was not incorporated into pyridoxol.

【 授权许可】

Unknown