期刊论文详细信息
FEBS Letters | |
Growth response to 4‐hydroxy‐l‐threonine of Escherichia coli mutants blocked in vitamin B6 biosynthesis | |
Leistner, Eckhard2  Drewke, Christel2  Hansen, Ursula2  Spenser, Ian D.1  Hemscheidt, Thomas1  Hill, Robert E.3  Notheis, Caroline2  | |
[1] Department of Chemistry, McMaster University, Hamilton, Ont., L8S 4M1, Canada;Institut für Pharmazeutische Biologie, Universität Bonn, D-5300 Bonn 1, Germany;Department of Pathology, McMaster University, Hamilton, Ont., L8S 4M1, Canada | |
关键词: Biosynthesis; Escherichia coli; Vitamin B6; Pyridoxol; 4-Hydroxy-l-threonine; 1-Aminopropan-2; 3-diol; | |
DOI : 10.1016/0014-5793(93)80005-F | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
Mutants of Escherichia coli (pdx B and pdx C) which are blocked in the biosynthesis of pyridoxol (vitamin B6) showed a growth response to 4-hydroxy-l-threonine. This observation constitutes the first direct evidence in support of the view that 4-hydroxy-l-threonine is implicated in the biosynthesis of vitamin B6. 1-Aminopropan-2,3-diol, the decarboxylation product of 4-hydroxy-l-threonine, does not support the growth of these mutants. Deuterium from deuterium-labelled 1-aminopropan-2,3-diol was not incorporated into pyridoxol.
【 授权许可】
Unknown
【 预 览 】
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