Loss of α‐tocopherol upon exposure to nitric oxide or the sydnonimine SIN‐1

FEBS Letters

Sies, Helmut¹  de Groot, Herbert¹  Hegi, Udo¹ 

[1] Institut für Physiologische Chemie I, Heinrich-Heine- Universität Düsseldorf, Moorenstrasse 5, D-4000 Düsseldorf, Germany

关键词: Vitamin E;    Nitric oxide;    Sydnonimine;   

DOI  :  10.1016/0014-5793(93)81150-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

SIN-1 which spontaneously decomposes to yield nitric oxide (NO^. and Superoxide anion (O₂ ^.− radicals caused a loss of microsomal α-tocopherol paralleled by the formation of α-tocopheryl quinone. The loss was partially prevented by Superoxide dismutase but not by catalase. The SIN-1-induced loss of α-tocopherol also occurred when tocopherol was dissolved in ethanol/potassium phosphate buffer (20/80, v/v). Likewise, addition of authentic NO^. to α-tocopherol dissolved in ethanol resulted in loss of the vitamin and quinone formation. These results suggest that NO^. or its products such as peroxynitrite or nitrogen dioxide react with α-tocopherol, the quinone derivative being a major oxidation product. Depletion of vitamin E by NO^. may contribute to tissue injury, e.g. in neuronal tissues.

【 授权许可】

Unknown