Interferon‐mediated intracellular signalling Modulation of different phospholipase activities in Burkitt lymphoma cells

FEBS Letters

Cataldi, A.²  Miscia, S.²  Toto, N.²  di Primio, R.²  Lisio, R.²  Bareggi, R.¹  Rana, R.² 

[1] Istituto di Anatomia Umana Normale, Università di Trieste, Trieste, Italy;Istituto de Morfologia Umana Normale, Università di Chieti, Chieti, Italy

关键词: Interferon;    Phospholipase;    Daudi cell;    PIP2;    phosphatidylinositol-bisphosphate;    IP3;    inositoltrisphosphate;    PA;    phosphatidic icid;    LPL;    less polar lipids.;   

DOI  :  10.1016/0014-5793(92)81193-P

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The effect of interferon-α on Daudi lymphoma cells either sensitive or resistant to the action of this cytokine has been analysed in terms of phospholipase C (PLC) and D (PLD) activities. Results have shown a combined modulation of PIP₂-specific phospholipase C and phospholipase D. In particular, a decreased activity of PIP₂-specific PLC has been found, concomitant to a PLD-mediated phosphatidylcholine hydrolysis, suggesting that the intracellular signaling activated by interferon in Daudi cells involves a phospholipase D/phosphohydrolase pathway.

【 授权许可】

Unknown