Angiotensin II induces formation of the early growth response gene‐1 protein in rat vascular smooth muscle cells

FEBS Letters

Weisser, Peter¹  zu Brickwedde, Katharina Meyer¹  Schulte, Kerstin¹  Neyses, Ludwig¹  Vetter, Hans¹  Ko, Yon¹  Sachinidis, Agapios¹ 

[1] Medizinische Universitäts-Poliklinik, Wilhelmstr, 35-37, D-5300 Bonn 1, Germany

关键词: Early growth responce gene-1 (Egr-1);    Angiotensin II;    Vascular smooth muscle cell;    VSMCs;    vascular smooth muscle cells;    DMEM;    Dulbecco's modified Eagles medium;    PBS;    Dulbecco's phosphate-buffered saline;    Ang II;    Angiotensin II;    Egr-1;    early growth response gene-1;   

DOI  :  10.1016/0014-5793(92)81423-J

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The effect of angiotensin II (Ang II) on the early growth response gene-1 (Egr-1) mRNA, on the Egr-1 protein and on the phosphoinositide PI turnover signalling system was investigated in the presence and absence of EXP3174, a potent non-peptide Ang II receptor antagonist. Ang II induced an accumulation of 3.4 kb Egr-1 mRNA and the 80 kDa Egr-1 protein, with a maximum at 30 min and 60 min, respectively. EXP3174 blocked the Ang II-induced increase of inositolphosphates, Egr-1 mRNA and the Egr-1 protein, suggesting the involvement of the PI signalling system by the expression of the Egr-1 gene.

【 授权许可】

Unknown