Cyclosporin A protects pancreatic islet cells from nitric oxide‐dependent macrophage cytotoxicity

FEBS Letters

Burkart, Volker¹  Imai, Yoichiro¹  Kolb, Hubert¹  Kallmann, Boris¹ 

[1] Diabetes-Forschungsinstitut an der Universität Düsseldorf, Auf'm Hennekamp 65, W-4000 Düsseldorf, Germany

关键词: Cyclosporin A;    Type I diabetes;    Islet cell;    Macrophage;    Nitric oxide;   

DOI  :  10.1016/0014-5793(92)81183-M

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

It has been shown earlier in an in-vitro model of inflammatory islet cell death that activated macrophages lyse islet cells via the release of nitric oxide. Here we report that cyclosporin A suppresses macrophage cytotoxicity. Control experiments showed that the immunosuppressive drug does not improve the defences of islet cells against nitric oxide but inhibits the release of nitric oxide from LPS-stimulated macrophages. This property of cyclosporin A may contribute to the preservation of β cell function seen in cyclosporin A-treated patients with recent onset type I diabetes.

【 授权许可】

Unknown