Loss of transcription factor AP‐1 DNA binding activity during lymphocyte aging in vivo

FEBS Letters

Radziszewska, Ewa¹  Sikora, Ewa¹  Kaczmarek, Leszek²  Kamińska, Bożena¹ 

[1] Department of Cellular Biochemistry, Nencki Institute of Experimental Biology, Pasteura 3, 02-093 Warsaw, Poland;Tissue Culture Facility, Nencki Institute of Experimental Biology, Pasteura 3, 02-093 Warsaw, Poland

关键词: Transcription factor;    c-fos;    c-jun;    Transcription factor;    c-fos;    c-jun;    Lymphocyte;    Aging;   

DOI  :  10.1016/0014-5793(92)80930-F

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The main feature of cellular senescence is cessation of cell proliferation. Protooncogene c-fos, which is required for the cell to enter into DNA synthesis, is repressed in senescent fibroblasts. Diminished expression of c-fos and impaired formation of AP-1, which is a complex of c-Fos and c-Jun proteins acting as a transcription factor, was found in lymphocytes derived from old (> 18 months) mice and stimulated with Con A. There were no differences in c-jun expression and formation of other transcription factors (AP-2 and AP-3) between lymphocytes isolated front old and young mice.

【 授权许可】

Unknown