Effect of heat‐shock on Plasmodium falciparum viability, growth and expression of the heat‐shock protein ‘PFHSP70‐I’ gene

FEBS Letters

Biswas, Sukla²  Sharma, Yagya D.¹  Joshi, Bindu¹ 

[1] Department of Biotechnology, All India Institute of Medical Sciences, New Delhi - 110029, India;Malaria Research Centre, 22 Sham Nath Marg, Delhi - 110054, India

关键词: Heat-shock protein;    Gene expression;    Human malaria parasite;    Fever;   

DOI  :  10.1016/0014-5793(92)81417-K

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Cultures of the human malaria parasite Plasmodium falciparum were subjected to heat-shock for varying times and temperatures and then tested for their viability, growth and expression of heat-shock protein. Results show that the majority of parasites remained viable after heat-shock but their growth was affected. However, the expression of the heat-shock protein ‘PFHSP70-I’ gene was enhanced after heat-shock. We conclude that malarial parasites are able to survive in vivo during fever probably due to the overexpression of the heat-shock protein gene.

【 授权许可】

Unknown