FEBS Letters | |
Intracellular signal transduction pathways that control pancreatic β‐cell proliferation | |
Sjöholm, Åke1  | |
[1] Department of Endocrinology, The Rolf Luft Center for Diabetes Research, Karolinska Institute, Karolinska Hospital, Box 60500, S-104 01 Stockholm, Sweden | |
关键词: Pancreatic islet; Insulin secretion; Protein kinase C; Cyclic nucleotide; Polyamine; N-protein; Cyclic AMP; adenosine-3′; 5′-cyclic monophosphate; cyclic GMP; guanosine-3′; 5′-cyclic monophosphate; DBI; diazepam binding inhibitor; DNA; deoxyribonucleic acid; GABA; γ-aminobutyric acid; GH; growth; hormone; GTP; guanosine trisphosphate; IGF-I; insulin-like growth factor I; PDGF; platelet-derived growth factor; Sp-cAMP[S]; stimulatory diastereomer of adenosine-3′; 5′-cyclic monophosphorothioate; TGF-β; transforming growth factor β; TPA; 12-O-tetradecanoylphorbol 13-acetate; | |
DOI : 10.1016/0014-5793(92)81373-T | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
This review focuses on the factors that regulate the proliferation of pancreatic islet β-cells in vitro, and in particular on the intracellular pathways that convey the mitogenic signal into a proliferative response. Substances as diverse as nutrients, polypeptides, cytokines, adrenergic agents, lithium, phorbol esters and cyclic AMP analogs are all able to stimulate or inhibit β-cell proliferation in a time- and concentration-dependent manner. The evidence for involvement of cyclic AMP, cyclic GMP, protein kinase C, inositol polyphosphates, GTP-binding proteins, polyamines and oncogenes is reviewed.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
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RO201912020296965ZK.pdf | 680KB | download |