Ligand‐activated ion channels may share common gating mechanisms with the Shaker potassium channel

FEBS Letters

Lee, Chyuan-Yih¹ 

[1] Chemical Dynamics Corporation, 204 Executive Drive, Guilderland, NY 12084, USA

关键词: NMDA receptor;    Ion channel;    Gating mechanism;    Electron transfer;   

DOI  :  10.1016/0014-5793(92)81372-S

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

This paper proposes a detailed gating mechanism for the N-methyl-d-aspartate (NMDA) channel. In the NMDARI subunit, the signal of agonist binding may be carried from Y456 to W590 through an electron transport chain, including W480 which could be the glycine modulatory site. The channel's opening may arise from repulsion between negatively charged W590s, analogous to W435s or the Shaker K⁺ channel. The cyclic nucleotide-gated channels may be activated by a similar mechanism, but the opening of nicotinic acetylcholine receptor (nAChR) channels is likely to be initiated by the formation of tyrosine radicals. The role of disulfide-bonded cysteines in the redox modulation can also be explained.

【 授权许可】

Unknown