Cloning and sequencing of mouse collagenase cDNA Divergence of mouse and rat collagenases from the other mammalian collagenases

FEBS Letters

Rousseau, Guy G.¹  Henriet, Patrick²  Eeckhout, Yves² 

[1] Hormone and Metabolic Research Unit, Université de Louvain and International Institute of Cellular and Molecular Pathology, Bruxelles, Belgium;Laboratoire de Chimie Physiologique (Connective Tissue Group), Université de Louvain and International Institute of Cellular and Molecular Pathology, Bruxelles, Belgium

关键词: Collagen;    Evolution;    Homology;    Matrix metalloproteinase;    Neutrophil;    Rodent;    ME;    metalloelastase;    MMP;    Matrix metalloproteinase;    NMRI;    Naval Medical Research Institute;    PCR;    polymerase chain reaction;    SSC;    sodium saline citrate (1x = NaCl 0.15M;    sodium citrate 0.015 M);    UTR;    untranslated region;   

DOI  :  10.1016/0014-5793(92)81323-E

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Mouse collagenase cDNA was cloned and sequenced. The deduced amino acid sequence was compared to those of the other mammalian collagenases and related matrix metalloproteinases. These comparisons, as well as those of some enzymatic properties, show that the rodent (mouse and rat) interstitial collagenases are very similar but differ more from the other interstitial collagenases than does human neutrophil collagenase. This supports the hypothesis that the order Rodentia is an outgroup to the other eutherian (placental) mammalian orders.

【 授权许可】

Unknown