Developmental expression of voltage‐sensitive K+ channels in mouse skeletal muscle and C2C12 cells

FEBS Letters

Lazdunski, Michel¹  Lesage, Florian¹  Attali, Bernard¹  Barhanin, Jacques¹ 

[1] Institut de Pharmacologie Moléculaire et Cellulaire, 660 route des Lucioles, Sophia Antipolis, 06560 Valbonne, France

关键词: Ionic channel;    Myoblast;    Myotube;    Differentiation;    Development;   

DOI  :  10.1016/0014-5793(92)81320-L

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The developmental expression of voltage-sensitive K⁺ channels was analyzed by Northern blot in mouse skeletal muscle. Of nine Shaker-like genes studied, eight are expressed in this mammalian muscle. Their expression is differentially regulated during development. The mouse cell line C₂C₁₂ has been used to study expression of voltage-sensitive K⁺ channels during in vitro myotube differentiation. Different voltage-sensitive K⁺ channel messages are also expressed in these cells which display a pattern of expression depending upon the differentiation stage. The message for the very peculiar K⁺ channel or IsK type could only be detected by polymerase chain reaction on skeletal muscle mRNA.

【 授权许可】

Unknown