Retinoic acid decreases retinoic acid and triiodothyronine nuclear receptor expression in the liver of hyperthyroidic rats

FEBS Letters

Garcin, H.¹  Coustaut, M.¹  Higueret, P.¹  Audouin, I.¹  Begueret, J.²  Pallet, V.¹ 

[1] Laboratoire de Nutrition, ISTAB, Av. des Facultés, Université Bordeaux 1, 33405 Talence Cedex, France;Laboratoire de Génétique, Av. des Facultés, 33405 Talence Cedex, France

关键词: Hyperthyroidism;    Retinoic acid;    Triiodothyronine nuclear receptor;    Retinoic acid nuclear receptor;    mRNA;   

DOI  :  10.1016/0014-5793(92)81306-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Retinoic acid (RA) and triiodothyronine (T₃) exert many of their actions by binding to specific nuclear receptors (respectively, RA receptor (RAR) and T₃) receptor (TR) belonging to a ‘superfamily’ of receptors. Some heterologous regulation of these receptors has been shown, and in particular regulation of the maximum binding capacity of TR by either retinol or RA. Now, using hyperthyroidic rats as a model, the effect of RA on binding capacity and on the mRNA levels of TR and RAR was investigated. The results show that the benefit of vitamin A treatment for the hyperthyroidic state, which has been described for a long time, could be the result of a down-heteroregulation of TR by RA, the active metabolite of retinol.

【 授权许可】

Unknown