The primitive metazoan Hydra expresses antistasin, a serine protease inhibitor of vertebrate blood coagulation: cDNA cloning, cellular localisation and developmental regulation

FEBS Letters

Mala, Carola¹  Greber, Martin¹  Bauer, Karin¹  Holstein, Thomas W.¹  David, Charles N.¹  Kurz, Eva¹ 

[1] Zoologisches Institut, Universität München, Luisenstraße 14, 8000 Munich 2, Germany

关键词: Antistasin;    Serine protease inhibitor;    Factor Xa;    Blood coagulation;    Hydra;   

DOI  :  10.1016/0014-5793(92)80791-E

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We have isolated and characterized cDNAs from Hydra which encode antistasin, a potent inhibitor of factor Xa in the vertebrate blood clotting cascade. Hydra antistasin is expressed in gland cells and represents a major class of transcripts from Hydra's head. Sequence analysis revealed that Hydra antistasin contains 6 internal repeats of a 25–26 amino acid sequence with a highly conserved pattern of 6 cysteine and 2 glycine residues identical to that in leech antistasin. Conservation of antistasin in a lower metazoan provides a potential link between the vertebrate and invertebrate coagulation systems.

【 授权许可】

Unknown