FEBS Letters | |
The primitive metazoan Hydra expresses antistasin, a serine protease inhibitor of vertebrate blood coagulation: cDNA cloning, cellular localisation and developmental regulation | |
Mala, Carola1  Greber, Martin1  Bauer, Karin1  Holstein, Thomas W.1  David, Charles N.1  Kurz, Eva1  | |
[1] Zoologisches Institut, Universität München, Luisenstraße 14, 8000 Munich 2, Germany | |
关键词: Antistasin; Serine protease inhibitor; Factor Xa; Blood coagulation; Hydra; | |
DOI : 10.1016/0014-5793(92)80791-E | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
We have isolated and characterized cDNAs from Hydra which encode antistasin, a potent inhibitor of factor Xa in the vertebrate blood clotting cascade. Hydra antistasin is expressed in gland cells and represents a major class of transcripts from Hydra's head. Sequence analysis revealed that Hydra antistasin contains 6 internal repeats of a 25–26 amino acid sequence with a highly conserved pattern of 6 cysteine and 2 glycine residues identical to that in leech antistasin. Conservation of antistasin in a lower metazoan provides a potential link between the vertebrate and invertebrate coagulation systems.
【 授权许可】
Unknown
【 预 览 】
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