Vitamin E dietary supplementation inhibits transforming growth factor β1 gene expression in the rat liver

FEBS Letters

Dianzani, Irma³  Barrera, Giuseppina¹  Parola, Maurizio¹  Piccoletti, Roberta²  Poli, Giuseppe¹  Bendinelli, Paola²  Muraca, Roberto¹  Leonarduzzi, Gabriella¹ 

[1] Dipartimento di Medicina ed Oncologia Sperimentale, Centro di Immunogenetica ed Oncologia Sperimentale CNR, Torino, Italy;Istituto di Patologia Generale, Università di Milano, Milano, Italy;Istituto di Clinica Pediatrica, Università di Torino, Torino, Italy

关键词: Liver fibrosis;    TGFβ1;    α2 (I) Procollagen;    Vitamin E;   

DOI  :  10.1016/0014-5793(92)81290-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Overexpression of transforming growth factor β1 (TGFβ1) and increased transcription of pro-collagen type I, are known to represent major events implicated in the development of liver fibrosis under either experimental or clinical conditions. Here we report that long-term dietary vitamin E supplementation in animals undergoing an experimental model of liver fibrosis (induced by chronic treatment of rats with carbon tetrachloride) results in a net inhibition of both hepatic TGFβ1 and α2 (I) procollagen mRNA levels. Moreover, of striking interest is the observation that vitamin E supplementation per so down-modulates basal levels of TGFβ1 mRNA in the liver of untreated animals, suggesting that a dietary regimen rich in vitamin E may potentially interfere with both the initiation and progression of the fibrosclerotic processes.

【 授权许可】

Unknown