Reversal of oxidative phosphorylation in submitochondrial particles using glucose 6‐phosphate and hexokinase as an ATP regenerating system

FEBS Letters

Galina, Antonio¹  Grieco, Maria Angela B.¹  de Meis, Leopoldo¹ 

[1]Instituto de Ciências Biomêdicas, Departamento de Bioquimica, Universidade Federal do Rio Janeiro, Cidade Universitária, Ilha do Fundáo, Rio de Janeiro, 21910, Brazil

关键词: Submitochondrial particle;    Membrane potential;    Glucose 6-phosphate;    Transhydrogenation;    NADP+;    NADH;   

DOI  :  10.1016/0014-5793(92)81273-O

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The different reaction measured with the use of glucose-6-phosphate and hexokinase were inhibited by glucose concentrations varying from 0.2 to 2 mM. Glucose shifts be equilibrium of the reaction towards glucose-6-phosphate formation thus leading to a decrease of the ATP concentration in the medium.

【 授权许可】

Unknown