Respiration driven Cl− uptake by submitochondrial particles

FEBS Letters

Selwyn, Michael J.¹  Comerford, John G.¹  Dawson, Alan P.¹ 

[1] School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, England

关键词: Anion channel;    Submitochondrial particle;    Membrane potential;    Mg2+;    Oligomycin;    FCCP;    carbonyl cyanide 4-(trifluoromethoxy)-phenylhydrazone;    Hepps;    N-2-hydroxyethylpiperazine-N′-3-propanesulphonic acid;   

DOI  :  10.1016/0014-5793(88)80814-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Both Mg²⁺ and oligomycin are required for the establishment of a membrane potential and the uptake of Cl⁻ in submitochondrial particles prepared from rat liver. The effect of oligomycin is considered to be due to blocking of H⁺ conduction through exposed F₀ channels of the ATPase complex whereas Mg²⁺ may more directly affect the anion-conducting channel.

【 授权许可】

Unknown