期刊论文详细信息
FEBS Letters | |
Human immunodeficiency virus type 1 productive infection in staurosporine‐blocked quiescent cells | |
Aranda-Anzaldo, A.1  Viza, D.1  | |
[1] URA-CNRS, Laboratoire d'Immumobiologie, Facultè de Mèdecine, 45, rue des Saints-Pères, 75006 Paris, France | |
关键词: Protein kinase inhibitor; Viral infectivity; Cel cycle; T cell; DMSO; dimethyl sulfoxide; HIV-1; human immunodeficiency virus type 1; IF; immunofluorescence; Mab; monoclonal anti-body; PBS; phosphate-buffered saline; p.i; post-infection; TCM; tissue culture medium; | |
DOI : 10.1016/0014-5793(92)81268-Q | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
Staurosporine, an antibiotic known to inhibit cellular protein kinases, can reversibly block the progress of normal and tumour cells into the cell cycle. The ability of HIV-1 to infect and replicate in cells blocked by staurosporine was investigated. The results show that blocked, non-cycling cells can be productively infected by HIV-1, steadily releasing infectious progeny virus for several weeks. This suggests that at least in some cases, HIV-1 can be found in a stable and active state in resting, non-proliferating T cells.
【 授权许可】
Unknown
【 预 览 】
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RO201912020296725ZK.pdf | 478KB | download |