Progesterone action through aggregation of a receptor on the sperm plasma membrane

FEBS Letters

Tesarik, J.¹  Fénichel, P.²  Mendoza, C.³  Fehlmann, M.⁴  Moos, J.⁵ 

[1]INSERM, Unitè 355, 32 Rue des Carnets, 92140 Clamart, and Center for Reproductive Biology and Medicine, American Hospital of Paris, 63 Boulevard Victor Hugo, 92202 Neuilly sur Seine, France

[2]INSERM, Unitè 210, Faculté de Médécine Pasteur, 06034 Nice, France

[3]Department of Biochemistry and Molecular Biology, University of Granada Faculty of Sciences, University Campus ‘Fuentenueva’, 18071 Granada, Spain

[4]Aster Biotechnologies, Les Nertiéres, 06610 La Grande, France

[5]Institute of Molecular Genetics, Videnska 1083, 14220 Prague, Czechoslovakia

关键词: Progesterone receptor aggregation;    Plasma membrane;    Calcium influx;    Acrosome reaction;    Sperm;    Human;   

DOI  :  10.1016/0014-5793(92)81256-L

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Rapid steroid effects, reported in several cell types, have pointed out the possibility of non-genomic mechanisms of action, presumably on cell surface receptors. Here we analyzed the effects of antibody-mediated aggregation of a novel type of progesterone receptor on the plasma membrane of human sperm cells. We report that aggregation of hormone-receptor complexes induces Ca²⁺ influx and a Ca²⁺-dependent exocytotic event in this system. These data suggest a possible mechanism for rapid steroid-induced events. Further research is warranted to examine if a similar mechanism is involved in rapid steroid effects in other cell types.

【 授权许可】

Unknown