In vitro interaction of fenretinide with plasma retinol‐binding protein and its functional consequences

FEBS Letters

Formelli, Franca²  Berni, Rodolfo¹ 

[1] Istituto di Scienze Biochimiche, Universitá di Parma, Viale delle Scienze, I-43100 Parma, Italy;Instituto Nazionale per to Studio e la Cura dei Tumori, Via Venezian 1, I-20133 Milan, Italy

关键词: Retinol-binding protein;    Fenretinide;    N-Ethylretinamide;    Retinoid binding;    Transthyretin;    Plasma retinol level;    RPB;    retinol-binding protein;    TTR;    transthyretin;   

DOI  :  10.1016/0014-5793(92)81046-O

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The synthetic retinoid fenretinide (4-HPR; N-[4-hydroxyphenyl] all-trans-retinamide) interacts with plasma apo-retinol-binding protein (RBP)to form a tight complex (λ^H _J = 0.2 μM) which does not exhibit binding affinity to transthyretin (TTR). Therefore, a substantial modification of the retinol hydroxyl group does not appear to affect the interaction with RBP but does drastically interfere with the protein—protein recognition. The remarkable early reduction in plasma retinol level induced by fenretinide administration may be associated with the high binding affinity of this retinoid to RBP and to its interference with the RBP—TTR complex formation.

【 授权许可】

Unknown