Depicting topology and handedness in jellyroll structures

FEBS Letters

Hutchinson, E.G.¹  Stirk, H.J.¹  Woolfson, D.N¹  Thornton, J.M.¹ 

[1] Biomolecular Structure and Modelling Unit, Department of Biochemistry and Molecular Biology, University College, Gower St., London WC1E 6BT, UK

关键词: Greek key;    Protein topology;    Jellyroll protein;   

DOI  :  10.1016/0014-5793(92)81036-L

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The jellyroll structure is a special case of the Greek key topology and, to date, has only been observed in complete form in one of its four possible arrangements. Like other elements of super-secondary structure involving the β-strand (eg. the βαβ unit) the known structure forms a right-handed superhelix. The possibility of losing such tertiary information and other problems associated with representing these structures by two-dimensional topology diagrams are discussed. A series of rules are presented which allow this three-dimensional information to be represented in two-dimensional topology diagrams from which the handedness of a jellyroll structure can be determined.

【 授权许可】

Unknown