Interleukin‐8, a chemotactic and inflammatory cytokine

FEBS Letters

Clark-Lewis, Ian¹  Baggiolini, Marco² 

[1] The Biomedical Research Centre and Department of Biochemistry, University of British Columbia, Vancouver, Canada;Theodor-Kocher Institute, University of Bern, Bern, Switzerland

关键词: Interleukin 8;    Receptor;    Biological function;    Neutrophil activation;    Pathophysiology;   

DOI  :  10.1016/0014-5793(92)80909-Z

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Interleukin-8 (IL-8) belongs to a family of small, structurally related cytokines similar to platelet factor 4. It is produced by phagocytes and mesenchymal cells exposed to inflammatory stimuli (e.g., interleukin-1 or tumor necrosis factor) and activates neutrophils inducing, chemotaxis, exocytosis and the respiratory burst. In vivo, IL-8 elicits a massive neutrophil accumulation at the site of injection. Five neutrophil-activating cytokines similar to IL-8 in structure and function have been identified recently. IL-8 and the related cytokines are produced in several tissues upon infection, inflammation, ischemia, trauma etc., and are thought to be the main cause of local noutrophil accumulation.

【 授权许可】

Unknown