Understanding the functions of titin and nebulin

FEBS Letters

Trinick, John¹ 

[1] Muscle and Collagen group, Department of Veterinary Medicine, Bristol University, Langford, Bristol, BS18 7DY, UK

关键词: Titin;    Nebulin;    Protein-ruler;    Twitchin;   

DOI  :  10.1016/0014-5793(92)80899-R

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Individual molecules of the giant muscle proteins titin and nebulin span large distances in the sarcomere. Approximately one-third of the titin molecule forms elastic filaments linking the ends of thick filaments to the Z-line. The remainder of the molecule is probably bound to the thick filament where it may regulate assembly of myosin and the other thick filament proteins. This region also contains a sequence similar to catalytic domains in protein kinases. Nebulin appears to be associated with thin filaments and may regulate actin assembly.

【 授权许可】

Unknown