Chlorpheniramine inhibits the ornithine decarboxylase induction of Ehrlich carcinoma growing in vivo

FEBS Letters

de Castro, I.Núñez¹  Urdiales, J.L.¹  Matés, J.M.¹  Sánchez-Jiménez, F.M.¹ 

[1]Cátedra de Bioquímica y Biologia Molecular, Facultad de Ciencias, Universidad de Màlaga, 29071 Malaga, Spain

关键词: Ornithine decarboxylase;    Chlorpheniramine;    Polyamine;    Tumor;   

DOI  :  10.1016/0014-5793(92)80682-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The antihistaminic (±)-chlorpheniramine significantly reduced the progression of Ehrlich carcinoma when it was administered at 0.5 mg/mouse/day from the third day on, after tumour inoculation. The ODC activity of tumour cells was diminished by 70% on day 7 after tumour transplantation, when maximum ODC activity is detected in non-treated tumour growing ‘in vivo’. Northern blot analyses indicated that the inhibitory effect of this 1,4-diamine takes place at a post-transcriptional level. Results obtained from serum-free cultured cells indicated that chlorpheniramine inhibits the ODC synthesis rate.

【 授权许可】

Unknown