The envelope glycoprotein of Ebola virus contains an immunosuppressive‐like domain similar to oncogenic retroviruses

FEBS Letters

Blinov, Vladimir M.¹  Volchkov, Viktor E.¹  Netesov, Sergey V.¹ 

[1] Institute of Molecular Biology, Koltsova, 633159 Novosibirsk Region, Russia

关键词: Ebola virus;    Immunosuppressive domain;    cDNA;    Amino acid sequence;    ARV;    avian reticuleondotheliosis virus (retrovirus);    FeLV;    feline leukemia virus (retrovirus);    RSV;    Rous sarcoma virus (retrovirus);    ASV;    avian sarcoma virus (retrovirus);    BAEV;    baboon endegenous virus (retrovirus);    HTLVIC;    human T-cell leukemia virus type I;    HTLV2;    human T-cell leukemia virus type I (retrovirus);   

DOI  :  10.1016/0014-5793(92)80662-Z

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Genomic RNA of a Zaire strain of Ebola virus was cloned, and cDNA inserts specific for the glycoprotein gene were isolated and sequenced. The determined sequence has only one open reading frame encoding 318 amino acids and is part of ORF-4 on the plus RNA strand. The putative transcriptional stop site (3′ AAUUCUUUUU 5′) and the transcriptional start site (3′ AACUACUUCUAAUU.. 5′) were identified. Computer-assisted comparison of the amino acid sequence of the C-terminal part of protein encoded by ORF-4 of Ebola virus with sequence of the proteins present in the SWISSPROT and EMBL banks revealed significant homology with the immunosuppressive domain of the p15E envelope proteins of various oncogenic retroviruses. The possible role of such a homology is discussed.

【 授权许可】

Unknown