Specific increase of a mitochondrial RNA transcript in chronic ethanol‐fed rats

FEBS Letters

Fernández-Silva, P.¹  López-Pérez, M.J.¹  Enriquez, J.A.¹  Pérez-Martos, A.¹  Montoya, J.¹ 

[1] Departamento de Bioquimica y Biologia Molecular y Celular, Facultad de Veterinaria, Universidad de Zaragoza, Miguel Servet 177, 50013 Zaragoza, Spain

关键词: Mitochondrion;    RNA synthesis;    Ethanol;    Isolated organelle;    Rat liver;   

DOI  :  10.1016/0014-5793(92)80639-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

An in vitro transcription system utilizing isolated mitochondria has been used to study the effect of chronic ethanol consumption on liver mitochondrial DNA transcription. The results obtained showed an overall increase of RNA synthesis and a dramatic accumulation of a discrete polyadenylated RNA species. This effect is a consequence of the chronic ethanol consumption since these changes do not occur when isolated control mitochondria are incubated in the presence of ethanol.

【 授权许可】

Unknown