Neopterin as an endogenous antioxidant

FEBS Letters

Kojima, Shuji¹  Icho, Takeshi²  Kubota, Kazuhiko¹  Kajiwara, Yoshio² 

[1] Research Institute for Biosciences, Science University of Tokyo, Tokyo, Japan;Laboratory of Asahi Breweries, Ltd., Research Institute for Biosciences, Science University of Tokyo, 2669 Yamazaki, Noda-shi, Chiba 278, Japan

关键词: Neopterin;    Antioxidant;    Alloxan diabetes;    NP;    neopterin;    NPH-4;    5;    6;    7;    8-tetrahydroneopterin;    BP;    biopterin;    CLA;    2-methyl-6-phenyl-3;    7-dihydroimidazo-(1;    2-α)-pyrazin-3-one;    SOD;    superoxide dismutase;    PMA;    phorbol myristate acetate;    XOD;    xanthine oxidase;    INF-γ;    interferon-γ;   

DOI  :  10.1016/0014-5793(92)80610-S

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The in vitro potency of neopterin (NP) as an antioxidant and its in vivo activity to suppress alloxan-induced diabetes were investigated. The reduced form of neopterin, 5,6,7,8-tetrahydroneopterin (NPH-4), showed an extremely high superoxide anion radical scavenging activity in two assay systems, i.e. xanthine/xanthine oxidase- and macrophage/phorbol myrislate acetate (PMA)-reaction systems. NPH-4 also inhibited the oxidation of linoleic acid about as effectively as uric acid. Furthermore, NPH-4 and NP effectively suppressed alloxan-induced mouse diabetes. These results suggest that pteridines play an important role as endogenous antioxidant.

【 授权许可】

Unknown