FEBS Letters | |
Polyamines enhance calcium mobilization in fMet‐Leu‐Phe‐stimulated phagocytes | |
Walters, John D.1  Chapman, Kena J.1  Sorboro, David M.1  | |
[1] Department of Periodontology, College of Dentistry, The Ohio State University, Columbus, OH 43210, USA | |
关键词: Polyamine; Calcium mobilization; Protein kinase C; Chemotactic peptide; Phagocytic leukocyte; fMLP; N-formylmethyionyl-leucylphenylalanine; fura-2/AM; fura-2 acetomethoxy ester; 1P3; inositol 1; 4; 5-trisphosphate; PDBu; phorbol 12; 13-dibutyrate; PKC; protein kinase C; PMN; polymorphonuclear leukocyte; | |
DOI : 10.1016/0014-5793(92)80584-4 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
Spermidine and putrescine (50 μM-1 mM), found in exudates from infection sites, significantly enhance fMet-Leu-Phe-induced Ca2+ mobilization in differentiated HL-60 cells and polymorphonuclear leukocytes (PMNs) by delaying the return to basal cytosolic Ca2+ levels. This enhancement by polyamines is associated with inhibition of Ca2+ efflux across the plasma membrane. In parallel with their effects on Ca2+ signaling, polyamines also significantly prolong the kinetics of fMet-Leu-Phe-induced protein kinase C translocation. Thus, polyamines may play a novel role in modulating regulatory events in phagocytes.
【 授权许可】
Unknown
【 预 览 】
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