Interleukin‐4 stimulates collagen gene expression in human fibroblast monolayer cultures Potential role in fibrosis

FEBS Letters

Kalis, B.¹  Banchereau, J.²  Maquart, F.X.³  Fertin, C.³  Gillery, P.³  Chastang, F.³  Nicolas, J.F.⁴ 

[1] Laboratoire de Recherche Biomédicale en Dermatologie, Faculté de Médecine, 51 Rue Cognacq Jay, 51095 Reims, cedex, France;Schering-Plough, Laboratoire de Recherches Immunologiques, BP 11, 69572 Dardilly, France;Laboratoire de Biochimie, CNRS URA 610, Faculté de Médecine, 51 Rue Cognacq Jay, 51095 Reims, cedex, France;INSERM U 346, Pavillon R, Hôpital Edouard Herriot, 69437 Lyon cedex 03, France

关键词: Interleukin-4;    Fibroblast;    Collagen synthesis;    Collagen gene expression: Fibrosis;   

DOI  :  10.1016/0014-5793(92)80448-P

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A role for the cytokines produced by tissue-infiltrated inflammatory cells (mainly T-lymphocytes and must cells) in the pathophysiology of fibrosis has been suggested by several groups. Among the products of these cells, interleukin-4 (IL-4) might be one of the factors involved in the initiation of the fibrotic process. We studied the effects of recombinant human IL-4 on human fibroblast monolayer cultures. IL-4 (10 and 100 U/ml) induced a dose-dependent increase of collagen production. Non-collagen protein synthesis was not significantly altered. A concomitant increase of pro-α1(I) collagen mRNAs was observed, showing that IL-4 acts at a pre-translational level.

【 授权许可】

Unknown