FEBS Letters | |
Transforming growth factors type‐β and dexamethasone attenuate group II phospholipase A2 gene expression by interleukin‐1 and forskolin in rat mesangial cells | |
Pignat, Werner3  Geiger, Thomas1  Märki, Fritz1  McMaster, Garry1  Pfeilschifter, Josef3  van den Bosch, Henk2  Mühl, Heiko3  Cerletti, Nico1  Cox, David1  Vosbeck, Klaus1  | |
[1] Research Department, Pharmaceuticals Division, Ciba-Geigy Ltd., CH-4002 Basel, Switzerland;Centre for Biomembranes and Lipid Enzymology, 3584 CH Utrecht, The Netherlands;Department of Pharmacology, Biocenter, University of Basel, CH-4056 Basel, Switzerland | |
关键词: Phospholipase A2; Interlaukin-1; Transforming growth factor β; Dexamethasone; Phospholipase A2 mRNA; Mesangial cell; PLA2; phospholipase A2; IL- 1; interleukin-1; TNF; tumour necrosis factor; TGF; transforming growth factor; | |
DOI : 10.1016/0014-5793(92)81245-H | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
Treatment of rat mesangial cells with interleukin-1β(IL-1β) and forskolin induced, in a synergistic fashion,the expression of group II phospholipase A2 (PLA2) mRNA, with subsequent increased synthesis and secretion of PLA2. In contrast, interleukin-6 did not increase PLA2 mRNA levels of PLA2 activity. Transforming growth factor (TGF) β1, TGFβ2 and TGFβ3 equipotently attenuated the IL-1β- and forskolin-induced elevation of PLA2 mRNA, as well as PLA2 synthesis and secretion. The glucocorticoid dexamethasone only partially suppressed the IL-1β- and forskolin-induced elevation of PLA2 mRNA, but totally inhibited PLA2 synthesis and secretion.
【 授权许可】
Unknown
【 预 览 】
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