Effect of TGFβ on liver genes expression Antagonistic effect of TGFβ on IL‐6‐stimulated genes in Hep 3B cells

FEBS Letters

Poli, V.¹  Morrone, G.²  Hassan, J.H.¹  Sorrentino, V.¹ 

[1] European Molecular Biology Laboratory, Meyerhofstrasse 1,6900 Heldeberg, Germany;Department of Experimental and Clinical Medicine, University of Catanzaro, Catanzaro, Italy

关键词: Transforming growth factor β;    Interleukin-6;    Liver gene expression;    Cytokine;   

DOI  :  10.1016/0014-5793(92)80197-O

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The effect of transforming growth factor beta (TGFβ) on the expression of a group of liver genes has been investigated in the hepatoma cell line Hep 3B. TGFβ induces a decrease of the basal level of apolipoprotein A-II (ApoA-II), retinol binding protein (RBP) α-fetoprotein (αFp). Furthermore, TGFβ efficiently antagonizes the IL-6-induction of hemopexin (Hpx) and haptoglobin (Hp) and α1-acid glycoprotein (AGP). These effects of TGFβ are apparently mediated by post-transcriptional mechanism(s). These findings, together with previously reported data on the inhibitory effect of TGFβ on acute phase genes (e.g. ApoA-I and albumin), suggest a role for TGFβ in the regulation of expression of liver genes.

【 授权许可】

Unknown